Zepbound
The most effective GLP-1 approved for weight loss.
What is Zepbound?
Zepbound is a dual GIP/GLP-1 receptor agonist — meaning it activates two gut hormones that regulate appetite and blood sugar.
In SURMOUNT-1, adults on the highest dose lost an average of 22.5% of body weight over 72 weeks — the largest reduction shown by any approved GLP-1 medication.
Slow and steady wins.
Once-weekly subcutaneous injection, titrated every 4 weeks based on tolerance.
Your provider may extend any dose level if you're tolerating well at a lower strength — there's no prize for moving up faster.
What to watch for, and what helps.
Most Zepbound side effects are GI-related and concentrated in the first weeks after each dose increase. Here's the playbook for managing each one.
Nausea
Most common in the first 2 weeks after each dose increase.
Diarrhea
Typically mild and resolves within a week.
Constipation
Increase fiber gradually and aim for 80oz of water daily.
Fatigue
Often tied to under-eating during titration.
Injection site reaction
Mild redness or itching is common.
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Find best price for ZepboundThis page is educational and not medical advice. Always consult your healthcare provider before starting, stopping, or changing any medication.